Learning the sequence of influenza A genome assembly during viral replication using point process models and fluorescence in situ hybridization
Identifieur interne : 000072 ( Main/Exploration ); précédent : 000071; suivant : 000073Learning the sequence of influenza A genome assembly during viral replication using point process models and fluorescence in situ hybridization
Auteurs : Timothy D. Majarian [États-Unis] ; Robert F. Murphy [États-Unis] ; Seema S. Lakdawala [États-Unis]Source :
- PLoS Computational Biology [ 1553-734X ] ; 2019.
Abstract
Within influenza virus infected cells, viral genomic RNA are selectively packed into progeny virions, which predominantly contain a single copy of 8 viral RNA segments. Intersegmental RNA-RNA interactions are thought to mediate selective packaging of each viral ribonucleoprotein complex (vRNP). Clear evidence of a specific interaction network culminating in the full genomic set has yet to be identified. Using multi-color fluorescence
Url:
DOI: 10.1371/journal.pcbi.1006199
PubMed: 30689627
PubMed Central: 6366722
Affiliations:
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Majarian</name><affiliation wicri:level="4"><nlm:aff id="aff001"><addr-line>Computational Biology Department, Carnegie Mellon University, Pittsburgh, Pennsylvania, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Computational Biology Department, Carnegie Mellon University, Pittsburgh, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université Carnegie-Mellon</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff002"><addr-line>Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université Carnegie-Mellon</orgName></affiliation></author><author><name sortKey="Murphy, Robert F" sort="Murphy, Robert F" uniqKey="Murphy R" first="Robert F." last="Murphy">Robert F. Murphy</name><affiliation wicri:level="4"><nlm:aff id="aff001"><addr-line>Computational Biology Department, Carnegie Mellon University, Pittsburgh, Pennsylvania, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Computational Biology Department, Carnegie Mellon University, Pittsburgh, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université Carnegie-Mellon</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff002"><addr-line>Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université Carnegie-Mellon</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff003"><addr-line>Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, Pennsylvania, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université Carnegie-Mellon</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff004"><addr-line>Machine Learning Department, Carnegie Mellon University, Pittsburgh, Pennsylvania, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Machine Learning Department, Carnegie Mellon University, Pittsburgh, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université Carnegie-Mellon</orgName></affiliation></author><author><name sortKey="Lakdawala, Seema S" sort="Lakdawala, Seema S" uniqKey="Lakdawala S" first="Seema S." last="Lakdawala">Seema S. Lakdawala</name><affiliation wicri:level="2"><nlm:aff id="aff005"><addr-line>Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author></analytic><series><title level="j">PLoS Computational Biology</title><idno type="ISSN">1553-734X</idno><idno type="eISSN">1553-7358</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Within influenza virus infected cells, viral genomic RNA are selectively packed into progeny virions, which predominantly contain a single copy of 8 viral RNA segments. Intersegmental RNA-RNA interactions are thought to mediate selective packaging of each viral ribonucleoprotein complex (vRNP). Clear evidence of a specific interaction network culminating in the full genomic set has yet to be identified. Using multi-color fluorescence <italic>in situ</italic> hybridization to visualize four vRNP segments within a single cell, we developed image-based models of vRNP-vRNP spatial dependence. These models were used to construct likely sequences of vRNP associations resulting in the full genomic set. Our results support the notion that selective packaging occurs during cytoplasmic transport and identifies the formation of multiple distinct vRNP sub-complexes that likely form as intermediate steps toward full genomic inclusion into a progeny virion. 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sortKey="De Castro Martin, If" uniqKey="De Castro Martin I">IF de Castro Martin</name></author><author><name sortKey="Fournier, G" uniqKey="Fournier G">G Fournier</name></author><author><name sortKey="Sachse, M" uniqKey="Sachse M">M Sachse</name></author><author><name sortKey="Pizarro Cerda, J" uniqKey="Pizarro Cerda J">J Pizarro-Cerda</name></author><author><name sortKey="Risco, C" uniqKey="Risco C">C Risco</name></author><author><name sortKey="Naffakh, N" uniqKey="Naffakh N">N Naffakh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lin, Jr" uniqKey="Lin J">JR Lin</name></author><author><name sortKey="Fallahi Sichani, M" uniqKey="Fallahi Sichani M">M Fallahi-Sichani</name></author><author><name sortKey="Sorger, Pk" uniqKey="Sorger P">PK Sorger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Comaniciu, D" uniqKey="Comaniciu D">D Comaniciu</name></author><author><name sortKey="Meer, P" uniqKey="Meer P">P 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Majarian</name></region><name sortKey="Lakdawala, Seema S" sort="Lakdawala, Seema S" uniqKey="Lakdawala S" first="Seema S." last="Lakdawala">Seema S. Lakdawala</name><name sortKey="Majarian, Timothy D" sort="Majarian, Timothy D" uniqKey="Majarian T" first="Timothy D." last="Majarian">Timothy D. Majarian</name><name sortKey="Murphy, Robert F" sort="Murphy, Robert F" uniqKey="Murphy R" first="Robert F." last="Murphy">Robert F. Murphy</name><name sortKey="Murphy, Robert F" sort="Murphy, Robert F" uniqKey="Murphy R" first="Robert F." last="Murphy">Robert F. Murphy</name><name sortKey="Murphy, Robert F" sort="Murphy, Robert F" uniqKey="Murphy R" first="Robert F." last="Murphy">Robert F. Murphy</name><name sortKey="Murphy, Robert F" sort="Murphy, Robert F" uniqKey="Murphy R" first="Robert F." last="Murphy">Robert F. Murphy</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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